![]() ![]() No significant differences between the groups after 24 months were noted regarding the tibial MNDL and the NDS. Statistically significant changes after 24 months between TA and PLA were observed (mean +/- SD) for sural SNCV: +3.8 +/- 4.2 m/s in TA 1200, +3.0+/-3.0m/s in TA 600, -0.1+/-4.8m/s in PLA (p < 0.05 for TA 1200 and TA 600 vs. At baseline no significant differences were noted between the groups regarding the demographic variables and peripheral nerve function parameters for these 65 patients. Statistical analysis was performed after independent reviewers excluded all patients with highly variable data allowing a final analysis of 65 patients (TA 1200: n = 18, TA 600: n = 27 PLA: n = 20). Severity of diabetic neuropathy was assessed by the Neuropathy Disability Score (NDS) and electrophysiological attributes of the sural (sensory nerve conduction velocity (SNCV), sensory nerve action potential (SNAP)) and the tibial (motor nerve conduction velocity (MNCV), motor nerve distal latency (MNDL)) nerve. The study was prospective, PLA-controlled, randomized, double-blind and conducted for two years. ![]() A trometamol salt solution of TA of 1200 or 600 mg or PLA was intravenously administered once daily for five consecutive days before enrolling the patients in the oral treatment phase. Therefore, Type 1 and Type 2 diabetic patients with symptomatic polyneuropathy were randomly assigned to three treatment regimens: (1) 2 x 600(mg of TA (TA 1200), (2) 600)mg of TA plus placebo (PLA) (TA 600) or (3) placebo and placebo (PLA). Even though the divisive “live-action” remakes of Disney classics likely won’t end anytime soon, Disney seems to have finally figured out the formula for a profitable, memorable, and charming animated sequel.Short-term trials with the antioxidant thioctic acid (TA) appear to improve neuropathic symptoms in diabetic patients, but the long-term response remains to be established. However, it's the latter that allows the legacy of Disney’s straight-to-video sequels survive – thrive, even – on Disney+, while the spirit of continuing to profit on nostalgia lives on in Disney’s modern remakes. The closure of Disneytoon Studios in 2018 marked the official end of straight-to-video sequels, which had long since become obsolete due to the fall of DVD sales and the rise of streaming. Pixar, under the direction of John Lasseter, led Disney into a new era of fully developed sequels, with the budget and production quality to match (sometimes exceed) their predecessors. Three of those sequels were animated by Pixar ( Incredibles 2, Toy Story 3, Toy Story 4) and the other ( Frozen 2) was by Walt Disney Animation Studios. Four of Disney’s top 10 highest-grossing animated films are now sequels. Mulan II generated at least $60 million, though it's unclear whether this number refers to domestic or worldwide sales. All of this convinced Disney to eventually make theatrical sequels to their biggest movies, an endeavor that has seen success with Ralph Breaks the Internet and Frozen 2.ĭespite the reputation garnered by straight-to-video sequels, Disney found sequel success with Pixar. Little Mermaid II: Return to the Sea and Lady and the Tramp II: Scamp's Adventure reportedly both made over $100 million. ![]() The Lion King grossed $766 million worldwide and had a production cost of $45 million. The pre-production for Lion King II was done by Walt Disney Animation Studios, which likely increased the budget, but Lion King II made a stunning $300 million in home video sales. ![]() The Lion King and The Lion King II: Simba's Pride each have similar profit margins. Return of Jafar raked in $300 million, but its cost to produce was a meager $3.5 million. The production cost of Aladdin was $28 million, but it grossed over $500 million worldwide, making it the highest-grossing film of 1992. Related: Every Live-Action Disney Remake, Ranked From Worst To Best ![]()
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